How Much Does Vyepti Infusion Cost?

Published on September 15, 2025 | Prices Last Reviewed for Freshness: February 2026
Written by Alec Pow - Economic & Pricing Investigator | Medical Review by Sarah Nguyen, MD

Educational content; not medical advice. Prices are typical estimates and may exclude insurance benefits; confirm with a licensed clinician and your insurer.

Vyepti is the only migraine preventive given by intravenous infusion on a quarterly schedule, which is why patients often ask how much it costs. The answer depends on the drug price per vial, the dose chosen by your specialist, and the place that administers the infusion. Cost also shifts with insurance, copay support, and whether you are treated in a hospital outpatient department, a physician office, an infusion center, or at home.

Vyepti is the brand name for eptinezumab. It is infused over about 30 minutes, four times a year. The FDA labeling recommends 100 mg every three months, with 300 mg available for patients who need a higher dose.

Article Insights

• Vyepti vials list at $1,940.07 per 100 mg; 2024 WAC disclosure shows $1,827.83.
• Typical administration ranges per infusion: office ~$536, hospital outpatient $2,695–$3,505, home infusion ~$186 under Medicare rates.
• Yearly drug totals at 100 mg are $7,311–$7,760, at 300 mg are $21,934–$23,281 before infusion fees.
• Commercial patients may pay $0 with copay support, with $200 per infusion for admin costs and yearly caps. Government plans are excluded.
• Moving from hospital outpatient to an office or home site often trims $1,500–$3,000 per infusion in high-price markets.
• Canada’s listed cost table sits near $1,665 per vial, illustrating international variance.

How Much Does Vyepti Infusion Cost?

The Vyepti Infusion has two widely cited costs: $1,940,07 and $1,827,83.

Lundbeck lists a public list price of $1,940.07 for one 100 mg single dose vial. Colorado pricing disclosures list the wholesale acquisition cost at $1,827.83 per 100 mg vial. The list price is higher than the acquisition price wholesalers see, and patients paying cash at retail may see even higher quotes.

Infusion and facility charges add a wide range on top of the drug. Hospital chargemasters often publish high “sticker” rates for the first infusion hour. One of the largest systems, Cedars-Sinai, posts a charge around $2,695 to $3,505 for CPT 96365 (initial infusion hour) before any discounts or insurer contracts apply. In physician offices, national commercial median prices observed for CPT 96413 are closer to $536 for the first hour, with $175 for each additional hour if needed. Home infusion under Medicare’s 2025 national rates pays providers about $186 for G0068 per IV visit, then locality adjustments apply.

At-a-glance ranges per infusion (drug plus administration), based on one 100 mg vial or three vials for 300 mg, are summarized below. Totals assume one infusion hour.

Drug figures draw from the list price and the 2024 WAC disclosure, administration figures from Cedars-Sinai, ASCO median office prices, and CMS 2025 home infusion rates. Real bills are often lower or higher once your plan’s allowed amounts and deductibles apply.

According to Drugs.com, Vyepti is administered as an intravenous infusion typically every three months for the preventive treatment of migraine in adults. The total cost for each infusion may vary due to additional fees for infusion administration, healthcare provider charges, and insurance coverage.

Healthline notes that many patients with commercial insurance may be eligible for the Vyepti Connect Copay Assistance Program, which can reduce out-of-pocket costs for the medication to as little as $0 per infusion, with maximum savings of up to $200 on administration fees per treatment. This program requires enrollment and approval and is designed to help eligible patients manage costs not covered by insurance.

GoodRX argues that patients without insurance or with high-deductible plans may encounter significant out-of-pocket expenses due to Vyepti’s high drug cost and related infusion procedures. Additional financial support options include manufacturer coupons, rebates, and discounts through various patient assistance programs, which patients should explore with their healthcare provider.

You might also like our articles on the cost of Reclast infusions, Iron infusions, or Revlimid.

Real-Life Cost Examples

Patient A, commercially insured with copay support. A 28-year-old in Phoenix receives 100 mg in an office site of care. With plan coverage and the Vyepti Connect copay program, out-of-pocket can be $0 per infusion, with the manufacturer also offsetting up to $200 of administration costs per visit, subject to annual caps and eligibility. The plan pays its contracted rate for the drug and infusion service.

Patient B, Medicare beneficiary without Medigap. A 67-year-old in Ohio receives 100 mg at a hospital outpatient clinic. The Part B drug is typically subject to 20 percent coinsurance after the deductible, so coinsurance on an allowed drug amount near the list price could run $350–$400, plus 20 percent of the hospital infusion fee, which might add $500–$700 in coinsurance if the hospital’s allowed amount is in the mid-thousands. Vyepti copay cards cannot be used with government programs. CMS publishes separate payment structures for home infusion, which can reduce the administration portion when clinically appropriate and allowed by the plan.

Patient C, uninsured cash payer. A patient in Florida fills through a specialty pharmacy and pays retail for three 100 mg vials for a 300 mg dose. SingleCare quotes about $9,343.94 for three vials without a coupon and $5,694.16 with its discount, then the infusion center charges a separate administration fee. If performed in an office with a typical one hour charge, the total could land near $6,230–$6,670 after the coupon. In a hospital outpatient department, the same infusion can clear $8,400–$9,900. Sticker shock is real.

Cost Breakdown

Medication. Vyepti comes in 100 mg single dose vials. Four 100 mg infusions per year tally $7,760 at the list price or about $7,311 at the disclosed wholesale acquisition cost. If you escalate to the 300 mg quarterly dose, the year uses 12 vials and the drug-only total rises to $23,281 at list or roughly $21,934 at WAC. These totals exclude infusion fees and any plan discounts.

Administration. A physician office often bills CPT 96413 for the initial infusion hour. ASCO-reported national commercial median prices are $536 for that first hour and $175 per additional hour, which Vyepti usually does not need because the infusion is about 30 minutes. Hospitals frequently bill CPT 96365 or a similar code on higher chargemaster rates, and large systems publicly list ranges like $2,695–$3,505 for the first hour, then additional time if used. Home infusion per 2025 Medicare rates pays $186 nationally for G0068 before local adjustments.

Supplies and facility fees. Some centers itemize supplies such as IV administration sets or port access kits that can add tens to a few hundred dollars, and several states have reported attention to facility fee growth. Public hospital reports in Colorado document how facility fees vary and why they appear on outpatient bills. Ask for itemized bills.

A worked example. A 45-year-old in Los Angeles receives 300 mg at a hospital outpatient department. Drug at list for three vials is $5,820, infusion first hour shows $2,695, and supplies add $100–$200 based on published hospital materials. The total per infusion is roughly $8,615–$8,715 before insurance, or about $34,460–$34,860 per year for the higher dose when charged at list and posted hospital rates. Contracted allowed amounts can be far lower, yet these public figures are a useful ceiling.

Factors Influencing the Cost

Dose and frequency. Most patients start at 100 mg, which limits drug outlay to one vial per visit, while some benefit from 300 mg, which triples the drug component.

Site of care. Moving from hospital outpatient to a physician office or home setting often reduces the administration portion by $1,500–$3,000 per infusion in markets where hospital chargemasters are several multiples of office medians, then plan contracts and site-of-care rules decide what you actually owe.

Region and payer policy. CMS publishes locality adjustments for home infusion payments that change year to year, commercial plans tailor allowed amounts by market, and some insurers publish site-of-care policies to steer high-cost biologics away from hospital outpatient departments when appropriate, which means two patients living just a few miles apart, but in different plan networks or counties, can face very different bills for the same 30-minute infusion.

International note. Canada’s CADTH review lists eptinezumab at about $1,665 per 100 mg vial in its cost tables, which is lower than current US list figures. Cross-border pricing cannot be used directly, yet it illustrates how regulated markets post different anchors.

Alternative Products or Services

CGRP-targeting injectables taken at home are the main alternatives. Aimovig lists $767.67 per month as of January 2025, Emgality lists $741.69 per 120 mg pen, and Ajovy cash prices on US coupon sites often start in the $700+ range per monthly supply. Vyepti’s 100 mg yearly drug total is $7,760 at list, while 300 mg totals $23,281, so drug-only annuals are in the same band as monthly autoinjectors at standard doses for 100 mg, then considerably higher for 300 mg. Administration costs make Vyepti more sensitive to where you infuse.

Some patients prefer the quarterly clinic visit and find adherence easier than monthly pens. Others prioritize the convenience and lower administrative charges of home injections. Your neurologist will weigh clinical response and tolerance, then your budget and plan rules often decide the winner.

Ways to Spend Less

Use the manufacturer copay program if you have commercial insurance and qualify. Vyepti Connect can reduce your drug copay to $0 and offset up to $200 per infusion in administration fees within annual caps. If your plan allows it, shift infusions to a physician office or home, which typically trims hundreds to a few thousand dollars per visit compared with hospital outpatient.

Ask your clinic to submit prior authorization early, confirm the site of care that your plan prefers, and get all expected CPT and HCPCS codes in writing to pre-check benefits. If you are uninsured, compare specialty pharmacy cash quotes and bring discount offers. Short paragraph, big impact.

Expert Insights & Tips

Neurologists often start at 100 mg and reassess at six months. The FDA label confirms the 100 mg recommendation and the option to escalate to 300 mg. Pharmacists point out that Vyepti is billed as a Part B drug in most employer and Medicare plans, so the benefit design and deductible timing influence your bill far more than for a Part D pharmacy claim.

Financial navigators recommend getting the infusion coded on an office claim when feasible. ASCO’s reported medians for 96413 and 96415 illustrate why office billing can be less than hospital outpatient charges for similar time on task. For Medicare patients who qualify clinically and logistically, home infusion payments published by CMS provide a predictable administration component, then the drug reimbursement follows separate Part B rules.

Total Cost of Ownership

Quarterly therapy creates predictable, large bills four times a year instead of smaller monthly charges. Annual drug totals sit around $7,311–$7,760 for 100 mg and $21,934–$23,281 for 300 mg, before administration. Add four administration fees. In an office setting, that might add about $2,144 across the year at the $536 median first hour, while a hospital outpatient path could add $10,780–$14,020 at posted ranges. Travel and time costs vary by city, yet many families report missing a half day of work each quarter, plus parking and transport.

Hidden & Unexpected Costs

Denied prior authorization can shift an infusion into a patient-pay event, which is expensive. Hospital facility fees and supply line items often appear on outpatient bills and may not be obvious in advance. Colorado’s 2024 report on facility fees explains how these charges show up and how payers handle them. Lab work, pre-infusion pregnancy tests when indicated, and observation charges after an infusion are occasional add-ons that can add $20–$200 per visit.

Warranty, Support & Insurance Costs

Vyepti Connect supports prior authorization and copay help for commercially insured patients, including real nurse support and direct reimbursement when clinics will not process the copay card. Government insurance is excluded by law, and the program has per-infusion and annual caps. Coverage policies vary, and some payers publish site-of-care rules that prefer office or home settings for biologics.

Financing & Payment Options

Many hospital systems and infusion centers offer no-interest payment plans for out-of-pocket balances if you enroll before the bill is past due. Physician offices sometimes accept installment plans for the administration portion. Specialty pharmacies that dispense the vials may also have payment options for cash transactions. If you use a health savings account, pre-fund contributions ahead of the quarterly bill cycle.

Answers to Common Questions

Is Vyepti covered by Medicare?

Yes, Vyepti is typically billed under Part B when administered by a provider, then coinsurance applies after the deductible. Home infusion services have a separate CMS payment structure under the HIT benefit, while the drug reimbursement follows Part B rules.

How often do you need Vyepti?

Vyepti is infused once every three months. The labeled recommended dose is 100 mg, and some patients use 300 mg when clinically appropriate, based on response and specialist guidance.

What does one infusion cost without insurance?

For 100 mg, drug at list is $1,940 plus an administration fee that ranges from about $536 in an office to $2,695–$3,505 in a hospital outpatient department in public postings. Total cash prices can be higher or lower depending on the site and any discounts.

Is there a cheaper alternative to Vyepti?

Home injectables like Aimovig and Emgality list around $742–$768 per month and avoid infusion fees. Annual drug-only costs for Vyepti at 100 mg are in a similar band to those options, then administration fees make the all-in total higher in many settings.

How long does each infusion session take?

About 30 minutes of infusion time per the manufacturer, with extra time for check in and observation. Many clinics book a one-hour slot.