How Much Does a Titer Test Cost?

Updated on September 2, 2026 | Written by Alec Pow
This article was researched using 11 sources. See our methodology and corrections policy.

A titer test currently costs about $49 to $142 for many individual or small immunity tests, while common multi-disease immunity panels cost roughly $173 to $305 when purchased directly from major laboratory services. More extensive occupational panels that combine immunity testing with tuberculosis screening can reach $600+.

Current examples include $49 for a hepatitis B surface antibody test, $59 for varicella IgG, $109 for an MMR panel, $173 including the service fee for a five-disease MMR + hepatitis B + varicella panel, and $219 for Labcorp’s comparable five-disease immunity panel.

The cheapest option is not always the cheapest-looking test. Before ordering anything, check the exact school, employer, clinical program, or licensing requirement. If acceptable vaccination records already establish immunity, a titer may not be required at all. If testing is required, buying five antibodies when the form asks for three wastes money, while buying a cheaper incomplete panel can force you to pay for a second blood draw.

Article Highlights

• Individual immunity blood tests currently start around $49 to $69 (at $30 per hour, earning that amount would take about 1.6 to 2.3 hours of work, before taxes) for common hepatitis B, varicella, and single-disease antibody tests.
• An MMR immunity panel currently costs about $109 to $142 in current direct-pay examples.
• A common MMR + hepatitis B + varicella panel costs about $173 to $219.
• Broader vaccination-status panels currently cost around $265 to $305 after published physician/service fees.
• A large Labcorp immunity-plus-TB screening panel currently costs $606.
• ThePricer math shows that bundling MMR, hepatitis B, and varicella with one provider can save about $48 versus buying those same tests separately.
• Tuberculosis blood testing is an IGRA, not an antibody titer, and should be priced separately unless specifically bundled.

How Much Does a Titer Test Cost?

Test or panel	Current cash price example	What it checks
Hepatitis B surface antibody	$49-$89 (about 1.6 to 3 hours of work at $30 per hour)	Hep B immunity marker
Varicella IgG	$59-$69	Chickenpox antibody
MMR immunity panel	$109-$142	Measles, mumps, rubella
MMR + Hep B + Varicella panel	$173-$219	Five common school/work immunity markers
Quest Basic Vaccination Status Panel	$265 including published physician fee	Eight diseases, but no hepatitis B
Quest Expanded Panel	$305 including published physician fee	Eleven disease markers including hepatitis B
TB QuantiFERON blood test	About $145-$205 in one current direct-order example	TB infection screening, not an antibody titer
Large immunity + TB panel	$606	Broad occupational screening

Request A Test currently prices its Hep B, MMR and varicella immunity panel at $169 through one laboratory option and $189 through another, plus a $4 per-order service fee. That makes the lower-priced option $173 before any unusual additional charge.

Labcorp OnDemand currently charges $219 for its five-disease Standard Immunity Test. It checks varicella, measles, mumps, rubella, and hepatitis B and uses in-person blood collection at a Labcorp location.

These are direct-pay examples rather than universal medical billing rates. A physician-ordered test billed through insurance can produce a very different negotiated price and out-of-pocket amount.

Buy the Exact Panel

The most useful cost calculation is not simply finding the lowest panel price. It is matching the test to the exact antibodies your form requires.

Suppose a nursing program asks for proof of immunity to:

• Measles
• Mumps
• Rubella
• Varicella
• Hepatitis B

Request A Test currently prices its MMR panel at $109 (about 3.6 hours of work at $30 per hour), hepatitis B surface antibody at $49, and varicella IgG at $59.

Bought separately:

$109 + $49 + $59 + $4 service fee = $221

The bundled panel covering those same five diseases starts at:

$169 + $4 service fee = $173

The bundle therefore saves:

$221 – $173 = $48

That is a saving of about 21.7% compared with buying those three orders separately through the same lower-price laboratory option.

Now compare the same five-disease requirement with Labcorp’s $219 panel. The $173 Request A Test option is $46 cheaper, or about 21% less. Both advertised panels cover the five diseases in this example, though ordering systems, laboratories, result formats, eligibility, and acceptance by your institution may differ.

Worked example: a student whose form requires only MMR, varicella, and hepatitis B considers Quest’s Expanded Vaccination Status Panel. The panel is currently $299 plus a $6 physician service fee, or $305. Compared with the $173 five-disease example, that is $132 more, an increase of about 76.3%. The Quest panel contains additional markers, so the extra money is not wasted laboratory work, but those extra results may have no value if the school does not require them.

This is the key ThePricer finding: the cheapest titer strategy is usually the smallest accepted set of tests, not the smallest sticker price and not the largest available bundle.

MMR Titer Cost

An MMR titer checks IgG antibodies associated with measles, mumps, and rubella. Request A Test currently charges $109 through one laboratory option and $124 through another for its MMR immunity test. Labcorp’s current MMR immunity test is $139, while Quest currently lists its MMR antibody panel at $142.

Before spending that money, check whether an antibody test is actually required. CDC says presumptive evidence of measles immunity can include written documentation of adequate vaccination, laboratory evidence of immunity, laboratory-confirmed disease, or qualifying birth-year criteria. For healthcare personnel with two documented appropriate MMR doses, serologic testing is generally not recommended just to reconfirm immunity.

The CDC’s current measles immunity guidance is particularly important when a school or employer gives you the choice between vaccination records and laboratory evidence.

Hepatitis B Titer Cost

The immunity test normally used for hepatitis B vaccine response is the hepatitis B surface antibody, or anti-HBs. Request A Test currently charges $49 through one lab and $59 through another for its hepatitis B surface antibody test. Labcorp OnDemand currently charges $89.

This test should not be confused with a broad hepatitis panel designed to look for evidence of current or previous infection. The marker matters. If an employer asks specifically for quantitative hepatitis B surface antibody, ordering a different hepatitis panel may not satisfy the paperwork.

CDC guidance for clinicians for whom post-vaccination testing is indicated recommends anti-HBs measurement roughly 1 to 2 months after the final vaccine dose. An anti-HBs level of at least 10 mIU/mL after a complete primary series is considered protective in this context.

For immunocompetent healthcare personnel who have already documented an adequate response, CDC says long-term protection is expected and periodic anti-HBs testing is not needed. There is no universal rule saying the result expires after ten years. See the current CDC healthcare hepatitis B guidance.

Varicella Titer Cost

A varicella-zoster virus IgG test checks for antibodies associated with chickenpox immunity. Request A Test currently charges $59 for its varicella IgG test, while Labcorp currently charges $69.

There is an important catch for vaccinated people. CDC says commercially available varicella IgG tests can fail to detect some vaccine-induced antibodies. A vaccinated person can therefore receive a negative commercial result despite having responded to vaccination.

For school-age children, adolescents, and adults, CDC recognizes documentation of two appropriate varicella vaccine doses as one form of evidence of immunity. Its varicella guidance specifically warns that commercial assays may produce false-negative results for vaccine-induced immunity.

This is one reason not to order a varicella titer automatically when acceptable vaccination documentation is already available.

TB Testing Is Not a Titer

Tuberculosis commonly appears on the same school and healthcare onboarding checklist as MMR, hepatitis B, and varicella, which is why it is often lumped into “titer testing.” Technically, a TB blood test is different.

CDC identifies the blood tests as interferon-gamma release assays, or IGRAs. They measure how white blood cells respond to TB proteins by releasing interferon-gamma. They do not measure protective vaccine antibodies in the way an MMR or hepatitis B immunity titer does.

Request A Test currently lists QuantiFERON-TB Gold Plus at about $145 through one laboratory option and $205 through another. Quest’s direct-pay TB blood test is currently $149.

CDC’s IGRA testing guidance explains the difference. Our separate guide to the cost of tuberculosis testing covers TB blood and skin-test pricing in more detail.

If a program asks for “MMR, varicella, Hep B and QuantiFERON,” price the first three as immunity markers and the QuantiFERON as an additional TB test.

The Hidden Cost of Adding TB

Adding one TB requirement can nearly double a low-cost immunity-panel budget.

Start with the $173 MMR + hepatitis B + varicella panel example. Add the current $145 lower-priced QuantiFERON example:

$173 + $145 = $318

TB screening adds approximately 83.8% to the original immunity-panel cost.

A more extensive ready-made product can cost considerably more. Labcorp currently lists a customizable Immunity and TB Screening Test for $606.

That is why students and new healthcare workers should obtain the exact onboarding checklist before clicking on a “complete healthcare panel.” The broadest package can cost hundreds more than a smaller set that satisfies the same institution.

Panels From Major Direct-Pay Labs

Quest’s current Basic Vaccination Status Panel costs $259 plus a $6 physician service fee, for a checkout price of $265. It tests antibody status for eight diseases: tetanus, diphtheria, pertussis, measles, mumps, rubella, varicella, and polio. Importantly, hepatitis B is not included.

Its Expanded Vaccination Status Panel costs $299 plus the same $6 fee, or $305. It adds hepatitis A, hepatitis B, and meningitis-related antibody testing for a total of 11 infectious-disease markers.

If a healthcare program specifically requires hepatitis B, paying $265 for the Basic panel would still leave that requirement unmet. Spending another $40 for the Expanded panel may therefore be cheaper than discovering the omission after the first blood draw.

The lesson is to compare what each panel contains, not merely count how many tests are advertised.

Insurance and Ordering Costs

Direct-pay prices are useful because they are visible before testing. Insurance pricing is less predictable. Your share can depend on medical necessity, why the test was ordered, network status, deductible, coinsurance, and whether the test is being performed for medical care or solely to satisfy employment or school paperwork.

Do not assume insurance will make an occupational titer free. Call the plan and ask about the exact laboratory test and ordering situation if coverage will determine where you go.

Direct-order services can also have small published fees. Request A Test currently adds $4 per order. Quest Health lists a physician service fee starting at $6 on its vaccination-status tests. Labcorp’s displayed direct-to-consumer panel price includes its stated ordering and collection pathway.

For a wider look at laboratory pricing, our guide to blood test costs explains how the test itself, facility, insurance contract, and ordering route can change what a patient pays. More specialized laboratory work, such as a karyotype test, belongs to a very different price category.

What We Verified

• Checked: current cash prices include $59 varicella IgG, $109 MMR, and $49 hepatitis B surface antibody through lower-priced Request A Test laboratory options.
• Confirmed: Labcorp’s current five-disease immunity panel costs $219 and uses in-person blood collection rather than an at-home finger-stick kit.
• Cross-referenced: CDC accepts documented vaccination as evidence of immunity in multiple contexts and does not recommend routine MMR serology for appropriately vaccinated healthcare personnel merely to reconfirm immunity.
• Verified: commercial varicella antibody tests may miss vaccine-induced immunity, so a negative post-vaccination titer does not automatically mean a vaccinated person lacks protection.
• Checked: CDC classifies TB blood tests as IGRAs measuring interferon-gamma response, not antibody titers.

Answers to Common Questions

How much is a titer test without insurance?
Common direct-pay individual immunity tests currently run about $49 to $142. A typical MMR + hepatitis B + varicella panel costs roughly $173 to $219, while larger occupational panels can cost $300 to $600+.

How much does an MMR titer cost?
Current direct-pay examples range from about $109 to $142 for a combined measles, mumps, and rubella immunity panel.

How long is a titer test valid?
There is no universal ten-year expiration date. Whether an old result is accepted depends on the disease, vaccination history, clinical circumstances, and the school or employer’s documentation policy. Some appropriately vaccinated people do not need repeat serologic testing at all.

Is a TB blood test a titer?
No. QuantiFERON and T-SPOT are interferon-gamma release assays used to test for TB infection. They measure a cellular immune response rather than an antibody titer.

Should I get titers if I already have my vaccine records?
Not automatically. Written vaccination documentation may already satisfy the medical or administrative requirement. Check the exact form first, especially for MMR and varicella, before paying for blood work that may not be necessary.

Educational pricing information only. Test selection and interpretation depend on the specific disease, vaccination history, medical circumstances, and institutional requirements. A clinician or occupational-health program should interpret results and advise on vaccination or further testing.